Nude mice veterinary medicine

Corynebacterium C. In , nude mice from an animal facility in Korea were found to have white flakes on their dorsal skin. Histopathological testing revealed that the mice had hyperkeratosis and Gram-positive bacteria were found in the skin. We identified isolated bacteria from the skin lesions as C. To the best of our knowledge, this is the first report of C. This microorganism is also the cause of epidermal hyperkeratosis in nude mice.

Good science and good animal care go hand in hand. A sick or distressed animal does not produce the reliable results that a healthy and unstressed animal produces. This unit describes the essentials of assessing mouse health, colony health surveillance, common conditions, and determination of appropriate endpoints. Understanding the health and well-being of the mice used in research enables the investigator to optimize research results and animal care. Both investigative and veterinary staffs monitor the health and well-being of mice that are used in research.

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Two major inbred strains of immuno-deficient mice are used to study the immune system and transplantation. These are nude mice, and SCID mice. A nude mouse is an inbred strain whose thymus gland is missing or damaged, resulting in a deficient immune system.